Rational Combination Immunotherapy: Understand the Biology.
Identifieur interne : 000C97 ( Main/Exploration ); précédent : 000C96; suivant : 000C98Rational Combination Immunotherapy: Understand the Biology.
Auteurs : Howard L. Kaufman [États-Unis]Source :
- Cancer immunology research [ 2326-6074 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- usage thérapeutique : Chloroquine.
- Animaux, Association de médicaments, Autophagie, Carcinome pulmonaire non à petites cellules, Humains, Immunothérapie, Tumeurs du poumon.
English descriptors
- KwdEn :
- Animals, Antineoplastic Agents, Immunological (therapeutic use), Autophagy (drug effects), CD47 Antigen (antagonists & inhibitors), CD47 Antigen (immunology), Carcinoma, Non-Small-Cell Lung (immunology), Carcinoma, Non-Small-Cell Lung (therapy), Chloroquine (therapeutic use), Drug Therapy, Combination, Humans, Immunotherapy, Lung Neoplasms (immunology), Lung Neoplasms (therapy).
- MESH :
- chemical , antagonists & inhibitors : CD47 Antigen.
- chemical , immunology : CD47 Antigen.
- chemical , therapeutic use : Antineoplastic Agents, Immunological, Chloroquine.
- drug effects : Autophagy.
- immunology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- therapy : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- Animals, Drug Therapy, Combination, Humans, Immunotherapy.
Abstract
Selecting rational treatment combinations remains a major challenge for improving immunotherapy outcomes. In this issue of Cancer Immunology Research, Zhang and colleagues reduced tumors by inhibiting CD47 in a lung carcinoma model, a treatment that inadvertently induced autophagy through inhibition of the Akt/mTOR pathway. By also targeting autophagy, the therapeutic response improved, highlighting the importance of understanding the biology beneath antitumor immunity. Cancer Immunol Res; 5(5); 355-6. ©2017 AACRSee article by Zhang et al., p. 363.
DOI: 10.1158/2326-6066.CIR-17-0128
PubMed: 28465453
Affiliations:
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Le document en format XML
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Kaufman</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Surgery and Medicine, Rutgers University, New Brunswick, New Jersey. howard.kaufman@rutgers.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Departments of Surgery and Medicine, Rutgers University, New Brunswick</wicri:cityArea></affiliation></author></analytic><series><title level="j">Cancer immunology research</title><idno type="eISSN">2326-6074</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antineoplastic Agents, Immunological (therapeutic use)</term><term>Autophagy (drug effects)</term><term>CD47 Antigen (antagonists & inhibitors)</term><term>CD47 Antigen (immunology)</term><term>Carcinoma, Non-Small-Cell Lung (immunology)</term><term>Carcinoma, Non-Small-Cell Lung (therapy)</term><term>Chloroquine (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Immunotherapy</term><term>Lung Neoplasms (immunology)</term><term>Lung Neoplasms (therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Association de médicaments</term><term>Autophagie ()</term><term>Carcinome pulmonaire non à petites cellules ()</term><term>Carcinome pulmonaire non à petites cellules (immunologie)</term><term>Chloroquine (usage thérapeutique)</term><term>Humains</term><term>Immunothérapie</term><term>Tumeurs du poumon ()</term><term>Tumeurs du poumon (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>CD47 Antigen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>CD47 Antigen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents, Immunological</term><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Immunotherapy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Association de médicaments</term><term>Autophagie</term><term>Carcinome pulmonaire non à petites cellules</term><term>Humains</term><term>Immunothérapie</term><term>Tumeurs du poumon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Selecting rational treatment combinations remains a major challenge for improving immunotherapy outcomes. In this issue of <i>Cancer Immunology Research</i>, Zhang and colleagues reduced tumors by inhibiting CD47 in a lung carcinoma model, a treatment that inadvertently induced autophagy through inhibition of the Akt/mTOR pathway. By also targeting autophagy, the therapeutic response improved, highlighting the importance of understanding the biology beneath antitumor immunity. <i>Cancer Immunol Res; 5(5); 355-6. ©2017 AACR</i><i>See article by Zhang et al., p. 363.</i></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>New Jersey</li></region></list><tree><country name="États-Unis"><region name="New Jersey"><name sortKey="Kaufman, Howard L" sort="Kaufman, Howard L" uniqKey="Kaufman H" first="Howard L" last="Kaufman">Howard L. Kaufman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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